Deuterated-Alkylation Reagents
Deuterium is a stable isotope of hydrogen with approximately double the mass of regular hydrogen (protium). Due to the kinetic isotope effect, carbon-deuterium (C-D) bonds are more resistant to cleavage than carbon-hydrogen (C-H) bonds. As a result, deuterated compounds generally exhibit greater metabolic stability than their non-deuterated counterparts.
Building on this advantage, deuterated pharmaceuticals (also referred to as heavy drugs) are attracting increasing attention as a promising drug development strategy. By replacing metabolically labile C-H bonds with C-D bonds, these compounds can achieve prolonged therapeutic activity.
FUJIFILM Wako offers a wide range of deuterated-alkylation reagents to support your drug discovery. We invite you to explore their potential in your research.
Sulfonium-Based Deuterated-Alkylation Reagents
FUJIFILM Wako has introduced a lineup of deuterated-alkylation reagents developed by Professor Sawama of Osaka University.
Features
- Electrophilic deuterated-alkylation reagents
- Solid form with no volatility; relatively stable to light and moisture
Application1)
- Ban, K., Imai, K., Oyama, S., Tokunaga, J., Ikeda, Y., Uchiyama, H., Kadota, K., Tozuka, Y., Akai, S. and Sawama, Y. : Angew. Chem. Int. Ed., 62, e202311058 (2023).
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For research use or further manufacturing use only. Not for use in diagnostic procedures.
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