Modified Nucleoside Triphosphates
Modified nucleoside triphosphates (NTPs) are nucleoside triphosphates where the nucleoside component--a key building block of DNA and RNA--has been chemically modified. One strategy to reduce the immunogenicity of mRNA vaccines and therapeutics, and to improve their stability, is to introduce chemically modified nucleosides with alterations in the base, sugar, or phosphate moieties.
What Are Nucleoside Triphosphates (NTPs)?
Nucleoside triphosphates (NTPs) are molecules composed of a nucleoside linked to three phosphate groups.
Modified Nucleoside Triphosphates
mRNA composed of natural nucleosides can activate innate immunity, leading to degradation of the mRNA and causing side effects when used in vaccines or therapeutics. A widely adopted strategy to address this issue involves replacing natural uridine or cytidine with modified nucleosides to reduce immunogenicity. FUJIFILM Wako offers a lineup of modified nucleoside triphosphates, including those incorporating an N¹-Methylpseudouridine structure, which has been used in COVID-19 vaccines.
Features
- Available in bulk quantities
- Comprehensive quality assurance
- Functionally tested in in vitro transcription
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