Anti Amyloid β Antibodies

Aβ is accumulated in the brain tissue of Alzheimer's disease patients. The accumulation of Aβ called "Senile plaque" can be observed in the tissue by staining with Aβ specific antibody. Aβ or Aβ polymerized Aβ oligomer is considered as a possible factor of Alzheimer's disease, therefore there are some research projects targeting Aβ. We offer various Aβ specific monoclonal antibodies which are developed by Takeda Pharmaceutical, Ltd. These antibodies have been used by many researchers, and used in several papers.

Aβ antibody Selection Guide
Aβ antibody
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Aβ antibody Selection Guide

Wako Cat. No.		10 μL	017-26871	014-26881	018-26921	014-26901	-
Wako Cat. No.		50 μL	013-26873	010-26883	014-26923	010-26903	012-27781
Clone No.			BAN50	BNT77	BA27	BC05	2C8
Host/Sub-class			Mouse/IgG1・κ	Mouse/IgA・κ	Mouse/IgG2a・κ	Mouse/IgG1・κ	Mouse/IgG2b
Application*			WB, IP, IHC, ICC, ELISA	IP, IHC, ELISA	WB, IHC, ELISA	WB, IHC, ELISA	WB, IHC
Antibody concentration			0.9-1.3 mg/mL	0.9-1.3 mg/mL	0.9-1.3 mg/mL	0.9-1.3 mg/mL	1.0 mg/mL
Aβ-Reactivity	Human	Aβ40	+	+	+	-	+
		Aβ42	+	+	-	+	+
		Aβ43	+	+	-	+	+
	Mouse/Rat	Aβ40	-	+	+	-	+
		Aβ42	-	+	-	+	+
		Aβ43	-	+	-	+	+

＊Application
WB=Western Blot, IP=Immunoprecipitation, IHC=Immunohistochemistry, ICC=Immunocytochemistry

Aβ antibody

Wako Cat. No.	Product Name				Grade		Package size
Human Aβ specific antibody
017-26871	Anti Human Amyloid β, Monoclonal Antibody (BAN50)				for immunochemistry		10 μL
013-26873	Anti Human Amyloid β, Monoclonal Antibody (BAN50)				for immunochemistry		50 μL
Antibody Information
Antigen	Amyloid β	Application*	WB, IP, IHC, ICC, ELISA	Isotype	IgG1・κ	■Immunostaining image Brain of Alzheimer's model mouse The data was provided by Kokawa, A., Hashimoto, T., and Iwatsubo, T., Graduate School of Medicine, University of Tokyo in Japan.
Antigen information	Human Amyloid β 1-16 a.a.	Species cross reactivity	Human	Label	Unlabeled
Antigen synonyms	-	Host	Mouse	Clone No.	BAN50
Summary	Amyloid β (Aβ) is a peptide which consists of about 40 amino acids. Aβ is considered the cause of Alzheimer's disease, because it is a major component of senile plaques formed in brains of Alzheimer's disease patients. This item is a mouse monoclonal antibody that reacts with N-terminal of human Aβ. The antibody was developed by Takeda Pharmaceutical Company Limited.
References	Asami-Odaka, A., et. al. : Biochemistry, 34(32), 10272 (1995). Fukumoto, H., et. al. : J. Neurosci., 30(33), 11157 (2010). Iwata, H., et. al. : J. Biol. Chem., 276(24), 21678 (2001).

Wako Cat. No.	Product Name				Grade		Package size
Aβ specific antibody
014-26881	Anti Amyloid β, Monoclonal Antibody (BNT77)				for immunochemistry		10 μL
010-26883	Anti Amyloid β, Monoclonal Antibody (BNT77)				for immunochemistry		50 μL
Antibody Information
Antigen	Amyloid β	Application*	IHC, IP, ELISA	Isotype	IgA・κ	■Immunostaining image Brain of Alzheimer's model mouse The data was provided by Kokawa, A., Hashimoto, T., and Iwatsubo, T., Graduate School of Medicine, University of Tokyo in Japan.
Antigen information	Human Amyloid β 11-28 a.a.	Species cross reactivity	Human, Mouse, Rat	Label	Unlabeled
Antigen synonyms	-	Host	Mouse	Clone No.	BNT77
Summary	Amyloid β (Aβ) is a peptide which consists of about 40 amino acids. Aβ is considered the cause of Alzheimer's disease, because it is a major component of senile plaques formed in brains of Alzheimer's disease patients. This item is a mouse monoclonal antibody that reacts with middle of Aβ. The antibody was developed by Takeda Pharmaceutical Company Limited.
References	Asami-Odaka, A., et. al. : Biochemistry, 34(32), 10272 (1995). Tomita, T., et. al. : J. Neurosci., 19(24), 10627 (1999). Sudoh, S., et. al. : J. Neurochem., 71(4), 1535 (1998).

Wako Cat. No.	Product Name				Grade		Package size
Aβ 40 specific antibody
018-26921	Anti Amyloid β 40, Monoclonal Antibody (BA27)				for immunochemistry		10 μL
014-26923	Anti Amyloid β 40, Monoclonal Antibody (BA27)				for immunochemistry		50 μL
Antibody Information
Antigen	Amyloid β40	Application*	WB, IHC, ELISA	Isotype	IgG2a・κ	■Immunostaining image Brain of Alzheimer's model mouse The data was provided by Kokawa, A., Hashimoto, T., and Iwatsubo, T., GraduateSchool of Medicine, University of Tokyo in Japan.
Antigen information	Human Amyloid β 1-40a.a.	Species cross reactivity	Human, Mouse, Rat	Label	Unlabeled
Antigen synonyms	-	Host	Mouse	Clone No.	BA27
Summary	Amyloid β (Aβ) is a peptide which consists of about 40 amino acids. Aβ is considered the cause of Alzheimer's disease, because it is a major component of senile plaques formed in brains of Alzheimer's disease patients. This item is a mouse monoclonal antibody that reacts with Aβ40. The antibody was developed by Takeda Pharmaceutical Company Limited.
References	Asami-Odaka, A., et. al. : Biochemistry, 34(32), 10272 (1995). Tomita, T., et. al. : J. Neurosci., 19(24), 10627 (1999). Iwatsubo, T. et al. : Am. J. Pathol., 149(6), 1823 (1996). Nonomura, A. et al. : J. Neuropathol. Exp. Neurol., 59(11), 1011 (2000).

Wako Cat. No.	Product Name				Grade		Package size
Aβ42 specific antibody
014-26901	Anti Amyloid β42 (43), Monoclonal Antibody (BC05)				for immunochemistry		10 μL
010-26903	Anti Amyloid β42 (43), Monoclonal Antibody (BC05)				for immunochemistry		50 μL
Antibody Information
Antigen	Amyloid β42,43	Application*	WB, IHC, ELISA	Isotype	IgG1・κ	■Immunostaining image Brain of Alzheimer's model mouse The data was provided by Kokawa, A., Hashimoto, T., and Iwatsubo, T., Graduate School of Medicine, University of Tokyo in Japan.
Antigen information	Human Amyloid β 35-43a.a.	Species cross reactivity	Human, Mouse, Rat	Label	Unlabeled
Antigen synonyms	-	Host	Mouse	Clone No.	BC05
Summary	Amyloid β (Aβ) is a peptide which consists of about 40 amino acids. Aβ is considered the cause of Alzheimer's disease, because it is a major component of senile plaques formed in brains of Alzheimer's disease patients. This item is a mouse monoclonal antibody that reacts with Aβ 42 and Aβ 43. The antibody was developed by Takeda Pharmaceutical Company Limited.
References	Asami-Odaka, A., et. al. : Biochemistry, 34(32), 10272 (1995). Tomita, T., et. al. : J. Neurosci., 19(24), 10627 (1999). Iwatsubo, T. et al. : Am. J. Pathol., 149(6), 1823 (1996). Nonomura, A. et al. : J. Neuropathol. Exp. Neurol., 59(11), 1011 (2000).

Wako Cat. No.	Product Name				Grade		Package size
Aβ specific antibody
012-27781	Anti Amyloidβ, Monoclonal Antibody(2C8)				for immunochemistry		50 μL
Antibody Information
Antigen	Amyloid β	Application*	WB, IHC	Isotype	IgG2ｂ	■Immunostaining image Alzheimer's model mouse (Red: Aβ)
Antigen information	1-16 a.a of human Amyloid β	Species cross reactivity	Human, Mouse	Label	Unlabeled
Antigen synonyms	-	Host	Mouse	Clone No.	2C8
Summary	Amyloid β（Aβ） is a peptide which consists of about 40 amino acids. Aβ is considered the cause of Alzheimer’s disease, because it is a major component of senile plaques formed in brains of Alzheimer’s disease patients. This antibody can be used not only in conventional immunostaining and western blot, but also in tissue clearing technique, SCALEVIEW-S.
References	Liu, Y., et. al. : J. Lipid Res., 45, 2368 (2004). Vehmas, A., et. al. : J. Neuroimmunol., 157(1-2), 99 (2004).

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