Anti Tau Antibodies

Tau is one of a microtubule-associated protein, which is mainly expressed in neurons of the central nervous system and regulates the stability of microtubules. In the brain of Alzheimer's disease, the accumulation of phosphorylated Tau called Neurofibrillary tangles is observed.
From the fact that Tau aggregates in the brain of Alzheimer's disease, there are some studies against Tau as a possible cause of the disease. Tau has over 40 sites of phosphorylation (Fig. 1) and 6 isoforms (Fig. 2). We offer the antibodies specific for some phosphorylation sites and isoforms.

Figure 1.　Tau phosphorylation sites

　　
Figure 2.　Tau isoforms

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Tau antibody Selection Guide
Total Tau Antibody
Phosphorylated Tau Antibody
Tau Isoform Antibody
Product List
Related Product List
Related Information

Tau antibody Selection Guide

Detectable Tau		Clone No.	Application*	Species cross reactivity	Host/Sub class	Epitope	Antibody concentration	Wako Cat. No.
Detectable Tau		Clone No.	Application*	Species cross reactivity	Host/Sub class	Epitope	Antibody concentration	10 μL	50 μL
Total Tau	Mouse, Rat, Human	RTM38	WB, IHC, ICC	Mouse, Rat, Human	Rat/IgG2a・κ	Tau (417-441 a.a.)	1.0-1.2 mg/mL	011-26891	017-26893
	Human specific	RTM49	WB, IHC, ICC	Human	Rat/IgG1・κ	Tau (2-44a.a.)	1.0-1.2 mg/mL	019-26951	015-26953
	Mouse specific	RTM47	WB, IHC, ICC	Mouse	Rat/IgG2b・κ	-	1.0-1.2 mg/mL	016-26961	012-26963
Phosphorylated Tau	Tau T181	2E2-A6	WB, IHC	Human	Rat/IgG2b・κ	Tau pT181	1.0-1.1 mg/mL	012-26603	016-26601
	Tau S199	5B8-1E2	WB, IHC	Human	Rat/IgG2a・κ	Tau pS199	1.0-1.1 mg/mL	019-26613	013-26611
	Tau S262	TIP1-35	WB, ICC, ELISA	Human	Rat/IgG1・λ	Tau pS262	0.9 mg/mL	014-27121	010-27123
	Tau S422	AP422	WB, IHC	Human, Mouse	Mouse/IgG1・κ	Tau pS422	1.0mg/mL	016-27681	012-27683
Tau isoform	2N-Tau	2C2	WB, IHC	Human	Rat/IgM・κ	Tau (74-103 a.a.)	1.0mg/mL	017-27351	013-27353
	3R-Tau	2A1-1F4	WB, IP	Human	Rat/IgG2b・λ	Tau (267-274, 306-313a.a.)	1.0-1.1 mg/mL	012-26583	016-26581
	4R-Tau	3E8-1A6	WB, IP	Human	Mouse/IgG1・κ	Tau (273-291a.a.)	1.0-1.1 mg/mL	019-26593	013-26591

＊Application
WB=Western Blot, IP=Immunoprecipitation, IHC=Immunohistochemistry, ICC=Immunocytochemistry

Total Tau Antibody

Wako Cat. No.	Product Name				Grade		Package size
Tau specific antibody
011-26891	Anti Human/Mouse/Rat Tau, Rat Monoclonal Antibody (RTM38)				for immunochemistry		10 μL
017-26893	Anti Human/Mouse/Rat Tau, Rat Monoclonal Antibody (RTM38)				for immunochemistry		50 μL
Antibody Information
Antigen	Tau	Application*	WB, IHC, ICC	Isotype	IgG2a・κ	■Immunohistochemistry Wild type mouse brain The data was provided by Miyasaka, T., Doshisha University in Japan
Antigen information	Mouse full length Tau 0N4R isoform	Species cross reactivity	Human, Mouse, Rat	Label	Unlabeled
Antigen synonyms	MAPT, Microtubule-Associated Protein Tau	Host	Rat	Clone No.	RTM38
Summary	Tau is a microtubule-associated protein, mainly expressed in neurons in the central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. This product is a rat monoclonal antibody that specifically recognizes human, mouse and rat Tau.
Reference	Kubo, A., et al. : J. Comp. Neurol., 527(5), 985 (2018).

Wako Cat. No.	Product Name				Grade		Package size
Human Tau specific antibody
019-26951	Anti Human Tau, Rat Monoclonal Antibody (RTM49)				for immunochemistry		10 μL
015-26953	Anti Human Tau, Rat Monoclonal Antibody (RTM49)				for immunochemistry		50 μL
Antibody Information
Antigen	Tau	Application*	WB, IHC, ICC	Isotype	IgG1・κ	■Immunohistochemistry Wild type mouse brain The data was provided by Miyasaka, T., Doshisha University in Japan
Antigen information	Human full length Tau 0N4R isoform	Species cross reactivity	Human	Label	Unlabeled
Antigen synonyms	MAPT, Microtubule-Associated Protein Tau	Host	Rat	Clone No.	RTM49
Summary	Tau is a microtubule-associated protein, mainly expressed in neurons in the central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. This product is a rat monoclonal antibody that specifically recognizes human Tau.
Reference	Kubo, A., et al. : J. Comp. Neurol., 527(5), 985 (2018).

Wako Cat. No.	Product Name				Grade		Package size
Mouse Tau specific antibody
016-26961	Anti Mouse Tau, Rat Monoclonal Antibody (RTM47)				for immunochemistry		10 μL
012-26963	Anti Mouse Tau, Rat Monoclonal Antibody (RTM47)				for immunochemistry		50 μL
Antibody Information
Antigen	Tau	Application*	WB, IHC, ICC	Isotype	IgG2b・κ	■Immunohistochemistry Wild type mouse brain The data was provided by Miyasaka, T., Doshisha University in Japan
Antigen information	Mouse Tau full length	Species cross reactivity	Mouse	Label	Unlabeled
Antigen synonyms	MAPT, Microtubule-Associated Protein Tau	Host	Rat	Clone No.	RTM47
Summary	Tau is a microtubule-associated protein, mainly expressed in neurons in the central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. This product is a rat monoclonal antibody that specifically recognizes mouse Tau.
Reference	Kubo, A., et al. : J. Comp. Neurol., 527(5), 985 (2018).

Phosphorylated Tau Antibody

Wako Cat. No.	Product Name				Grade		Package size
Phosphorylated Tau (T181) specific antibody
012-26603	Anti Phosphorylated Tau T181, Rat Monoclonal Antibody (2E2-A6)				for immunochemistry		10 μL
016-26601					for immunochemistry		50 μL
Antibody Information
Antigen	Tau T181	Application*	WB, IHC	Isotype	IgG2b・κ	■Immunostaining image Brain of Alzheimer's disease patient The data was provided by Miyasaka, T., Doshisha University in Japan.
Antigen information	171-191 a.a of Human Tau with pT181.	Species cross reactivity	Human	Label	Unlabeled
Antigen synonyms	-	Host	Rat	Clone No.	2E2-A6
Summary	Tau is a microtubule-associated protein, mainly expressed in neurons in central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. This product is an antibody that specifically recognizes Tau with phosphorylated threonine at position 181 (pT181).
Reference	-

Wako Cat. No.	Product Name				Grade		Package size
Phosphorylated Tau (S199) specific antibody
019-26613	Anti Phosphorylated Tau S199, Rat Monoclonal Antibody (5B8-1E2)				for immunochemistry		10 μL
013-26611					for immunochemistry		50 μL
Antibody Information
Antigen	Tau pT199	Application*	WB, IHC	Isotype	IgG2a・κ	■Immunostaining image Brain of Alzheimer's disease patient The data was provided by Miyasaka, T., Doshisha University in Japan
Antigen information	189-209 a.a of human Tau with pS199.	Species cross reactivity	Human	Label	Unlabeled
Antigen synonyms	-	Host	Rat	Clone No.	5B8-1E2
Summary	TTau is a microtubule-associated protein, mainly expressed in neurons in central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. This product is an antibody that specifically recognizes Tau with phosphorylated serine at position 199 (pS199).
Reference	-

Wako Cat. No.	Product Name				Grade		Package size
Phosphorylated Tau (S262) specific antibody
014-27121	Anti Phosphorylated Tau S262, Rat Monoclonal Antibody (TIP1-35)				for immunochemistry		10 μL
010-27123					for immunochemistry		50 μL
Antibody Information
Antigen	Tau pS262	Application*	WB, ICC, ELISA	Isotype	IgG1	-
Antigen information	-	Species cross reactivity	Human, monkey	Label	Unlabeled
Antigen synonyms	-	Host	Rat	Clone No.	TIP1-35
Summary	Tau is a microtubule-associated protein, mainly expressed in neurons in central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. This product is an antibody that specifically recognizes Tau with phosphorylated serine at position 262 (pS262).
Reference	-

Wako Cat. No.	Product Name				Grade		Package size
Phosphorylated Tau (S422) specific antibody
016-27681	Anti Phosphorylated Tau S422, Monoclonal Antibody (AP422)				for immunochemistry		10 μL
012-27683	Anti Phosphorylated Tau S422, Monoclonal Antibody (AP422)				for immunochemistry		50 μL
Antibody Information
Antigen	Tau pS422	Application*	WB, IHC	Isotype	IgG1・κ	■Immunostaining image Brain of Alzheimer's disease patient The data was provided by Dr, Hasegawa, M., Tokyo Metropolitan Institute of Medical Science in Japan.
Antigen information	CGG+417-427a.a. of human tau with pS422	Species cross reactivity	Human, Mouse	Label	Unlabeled
Antigen synonyms	-	Host	Mouse	Clone No.	AP422
Summary	Tau is a microtubule-associated protein, mainly expressed in neurons in central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. This product is an antibody that specifically recognizes Tau with phosphorylated serine at position 422 (pS422).
References	Hasegawa, M., et al. : FEBS Lett., 384(1), 25 (1996). Goedert, M., et al. : FEBS Lett., 409(1), 57 (1997). Buée-Scherrer, V., et al. : FEBS Lett., 515(1), 151 (2002). Delobel, P., et al.: J. Neurochem., 83(2), 412 (2002). Bellucci, A., et al. : Am. J. Pathol., 165(5), 1643 (2004). Sylvie, L. C., et al. : PNAS, 103(25), 9673 (2006). Schindowski, K., et al. : Am. J. Pathol., 169(2), 599 (2006). Audouard, E., et al. : Am. J. Pathol., 186(10), 2709 (2016).

Tau Isoform Antibody

Wako Cat. No.	Product Name				Grade		Package size
2N-Tau specific antibody
017-27351	Anti 2N-Tau, Rat Monoclonal Antibody (2C2)				for immunochemistry		10 μL
013-27353	Anti 2N-Tau, Rat Monoclonal Antibody (2C2)				for immunochemistry		50 μL
Antibody Information
Antigen	2N-Tau	Application*	WB, IHC	Isotype	IgM・κ	■Immunohistchemistry Alzheimer's disease patient's brain section The data was provided by Miyasaka, T., Doshisha University in Japan
Antigen information	Human Tau full length	Species cross reactivity	Human	Label	Unlabeled
Antigen synonyms	-	Host	Rat	Clone No.	2C2
Summary	TTau is a microtubule-associated protein, mainly expressed in neurons in the central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. Tau has 6 isoforms: 2N4R (Tau-441) , 2N3R (Tau-410) , 1N4R (Tau-412) , 1N3R (Tau-381) , 0N4R (Tau-383) , and 0N3R (Tau-352). This product is an antibody that specifically recognizes 2N4R and 2N3R Tau isoforms.
Reference	-

Wako Cat. No.	Product Name				Grade		Package size
3-Repeat Tau (3R-Tau) specific antibody
012-26583	Anti 3R-Tau, Rat Monoclonal Antibody (2A1-1F4)				for immunochemistry		10 μL
016-26581	Anti 3R-Tau, Rat Monoclonal Antibody (2A1-1F4)				for immunochemistry		50 μL
Antibody Information
Antigen	3R-Tau	Application*	WB, IP	Isotype	IgG2b・λ	■WB image Human tau recombinant mixtures (2N4R, 2N3R, 1N4R, 1N3R, 0N4R, 0N3R-Tau) The data was provided by Miyasaka, T., Doshisha University in Japan.
Antigen information	Human Tau 267-274, 306-313a.a	Species cross reactivity	Human	Label	Unlabeled
Antigen synonyms	-	Host	Rat	Clone No.	2A1-1F4
Summary	TauTau is a microtubule-associated protein, mainly expressed in neurons in the central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. Tau is classified into 3R-Tau and 4R-Tau which has 3 and 4 microtubules associated domains, respectively, This product is an antibody that specifically recognizes 3R-Tau.。
Reference	-

Wako Cat. No.	Product Name				Grade		Package size
4 Repeat Tau (4R-Tau) specific antibody
019-26593	Anti 4R-Tau, Monoclonal Antibody (3E8-1A6)				for immunochemistry		10 μL
013-26591	Anti 4R-Tau, Monoclonal Antibody (3E8-1A6)				for immunochemistry		50 μL
Antibody Information
Antigen	4R-Tau	Application*	WB, IP	Isotype	IgG1・κ	■WB image Human tau recombinant mixtures (2N4R, 2N3R, 1N4R, 1N3R, 0N4R, 0N3R-Tau) The data was provided Miyasaka, T., Doshisha University in Japan.
Antigen information	Human Tau 273-291a.a.	Species cross reactivity	Human	Label	Unlabeled
Antigen synonyms	-	Host	Mouse	Clone No.	3E8-1A6
Summary	Tau is a microtubule-associated protein, mainly expressed in neurons in the central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. Tau is classified into 3R-Tau and 4R-Tau which has 3 and 4 microtubules associated domains, respectively, This product is an antibody that specifically recognizes 4R-Tau.
Reference	-

Anti Tau Antibodies

Figure 1.　Tau phosphorylation sites

Figure 2.　Tau isoforms

Tau antibody Selection Guide

Total Tau Antibody

Phosphorylated Tau Antibody

Tau Isoform Antibody

Product List

Total Tau Antibodies

Phosphorylated Tau Antibodies

Tau Isoform Antibodies

Related Product List

Tau ELISA and Phospho-Tau ELISA

Amyloid β Antibodies

Amyloid β ELISA & Amyloid β oligomer ELISA

Anti Tau Antibodies

Figure 1. Tau phosphorylation sites

Figure 2. Tau isoforms

Tau antibody Selection Guide

Total Tau Antibody

Phosphorylated Tau Antibody

Tau Isoform Antibody

Product List

Total Tau Antibodies

Phosphorylated Tau Antibodies

Tau Isoform Antibodies

Related Product List

Tau ELISA and Phospho-Tau ELISA

Amyloid β Antibodies

Amyloid β ELISA & Amyloid β oligomer ELISA

Related Information

Category

Content

Figure 1.　Tau phosphorylation sites

Figure 2.　Tau isoforms